T2 thyroid hormone is rising as an extremely necessary and potent thyroid hormone.
And tons and tons of thyroid sufferers are taking discover.
This has led many a thyroid affected person to ask themselves an necessary query:
“How can I test my own T2 level to see if I should take it?”.
If this thought has crossed your thoughts then you might be in the precise place.
Let’s speak extra about T2 testing, why T2 thyroid hormone is so helpful to thyroid sufferers, and learn how to decide in the event you ought to strive it:
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Can You Take a look at For T2 Thyroid Hormone?
Let’s begin with the dangerous information:
At present, there is no such thing as a commercially accessible T2 check for thyroid sufferers.
Which means that, sadly, you aren’t going to have the ability to check your T2 stage such as you would your free T3 or free T4.
This doesn’t imply that you could’t make extremely educated guesses about your T2 standing (which we’ll speak about under).
And it positively doesn’t imply that there are not any T2 exams interval, it simply implies that they aren’t available for you and me.
That is for a few causes:
The primary is that the accessible exams aren’t fairly as correct as we’d like.
There are numerous totally different ways in which researchers can assess T2 standing for analysis functions, however lots of them fail to supply correct outcomes as a result of they aren’t sufficiently correct when T2 ranges are low (1).
A few of these T2 exams miss as much as 1/3 of sufferers with low T2 ranges.
The second is that we’re nonetheless studying about T2, its features within the cell and on thyroid hormone receptors, and the way it’s sure and carried by way of the physique.
This data is well-known for thyroid hormones like T3 and T4 which is why we’ve got exams like free T3, free T4, complete T3, and reverse T3.
Researchers higher perceive the lifecycle of those hormones, how they’re carried by way of the blood, and the way they work together with thyroid hormone receptors.
Whereas we do know that T2 exerts highly effective results on many various programs within the physique, and interacts with the thyroid hormone receptor (2), there’s nonetheless lots left to study.
Simply because you may’t check in your T2 stage such as you would, let’s say, your T3 stage, doesn’t imply that you could’t estimate how a lot T2 is in your physique or in the event you would profit from taking a T2 complement.
So, not less than for now, educated guessing is the one strategy to inform in the event you would seemingly profit from taking T2.
I perceive that for a lot of thyroid sufferers, this isn’t the perfect state of affairs, however the one different is to only keep away from T2 till industrial testing is out there which can take a number of years.
However in the event you don’t like the concept of sitting and ready whereas these exams are developed, then listed here are some methods that you could estimate your T2 standing.
Proxy Measurements To Inform if You Want Extra T2
These exams are what I name proxy measurements and whereas it could be most well-liked to have a real T2 check accessible, these measurements can nonetheless provide you with a number of details about your thyroid standing.
Right here’s how they work:
Whereas we might not have a great way to evaluate T2 ranges within the physique, we’ve got a fairly good thought of how T2 features.
So what we will do is have a look at the programs that T2 impacts to see if it’s doing what it ought to be doing.
If it isn’t, then we will make an informed guess that there’s most likely not sufficient T2 within the system.
And this technique of evaluating thyroid hormone shouldn’t be stunning to lots of you as a result of it’s one thing that we regularly do for evaluating T4 and T3 ranges.
If you’re taking a thyroid remedy like levothyroxine and nonetheless experiencing signs like weight achieve or hair loss, then you can also make an informed guess that you just most likely aren’t getting sufficient of it.
The first distinction right here is that you just’d have the ability to verify your suspicions with thyroid lab exams, which isn’t one thing we will do, however we will nonetheless do the primary half.
How correct is that this technique of proxy measurements?
Based mostly on my expertise, they’re pretty correct.
I say that as a result of I’ve had the benefit of monitoring and interacting with hundreds of people that have used my very own T2 complement and we hardly ever ever see issues utilizing this technique.
With this in thoughts, let’s speak about these proxy measurements:
#1. Resting Coronary heart Price
The primary is a straightforward metric that you could check at residence proper now.
Right here’s the way it works:
Your coronary heart incorporates thyroid hormone receptors (3) that are identified to be delicate to T2 thyroid hormone.
We all know this as a result of excessively excessive doses of T2 (not the kind of dose you’ll discover in a complement) may cause cardiac enlargement (4).
This enlargement doesn’t occur with regular doses, however the truth that it occurs with excessive doses tells us that T2 has some impression on the center.
Within the hypothyroid T2 poor state, we might anticipate that the center charge would decline to a low stage and that is precisely what we see in lots of thyroid sufferers.
Simply utilizing this measurement alone might be difficult, although, as a result of we additionally know that T3 thyroid hormone acts on the center as properly.
So if you’re a thyroid affected person taking levothyroxine (which incorporates T4) and experiencing a low resting coronary heart charge, how are you aware in case your drawback is with T3 or T2?
Nicely, the obvious strategy to inform the distinction is with testing.
You’ll be able to’t check for T2, however you may positively check for T3.
When you’ve got a low resting coronary heart charge AND you’re taking levothyroxine AND your free T3 is comparatively regular then, by strategy of elimination, solely T2 thyroid hormone is left.
And on this state of affairs, it could be a really cheap thought to strive T2 supplementation.
One of many finest issues about this measurement is that it’s really easy to check for.
All you want to do is use your pulse, rely for 15 seconds, after which multiply that quantity by 4 to provide you your resting coronary heart charge.
For finest outcomes, be sure to examine your pulse very first thing within the morning.
Alternatively, in the event you don’t wish to do the guide technique, you can even use a wearable system like an Apple watch or Fitbit.
A traditional resting coronary heart charge is someplace between 60 to 80 beats per minute.
If you end up in a hypothyroid state, you could discover that your resting coronary heart charge is within the 50 beats per minute vary which might be extremely indicative that your coronary heart will not be getting sufficient thyroid hormone (T3 or T2).
From right here it’s only a matter of experimenting with T2 to see in the event you can convey that resting coronary heart charge again up and higher management your different thyroid signs.
The second proxy measurement you may have a look at is your metabolism.
So far as thyroid hormones go, T2 is a serious regulator of metabolism and it could even be extra necessary on this regard than T3.
Proper now there’s a number of effort and analysis evaluating T2 as a possible weight reduction remedy (5), however this analysis continues to be ongoing.
When thyroid hormones are low (each T2 and T3), your metabolism will drop in response.
That is seemingly as a result of impression that these hormones have on hypothalamic operate, mitochondrial vitality manufacturing, and leptin signaling (6).
Both approach, a sluggish or low metabolism is a possible signal of a hypothyroid T2 poor state.
Very similar to the instance above, T3 additionally performs a job in regulating your metabolism so having a sluggish metabolism doesn’t mechanically imply you’ve got low T2.
However, once more, similar to the instance above, you may differentiate between T3-related low metabolism and T2-related low metabolism with testing.
In case your metabolism is low and your T3 is okay then it’s seemingly that T2 is enjoying some position.
Testing your metabolism is definitely fairly tough so as a substitute of making an attempt to evaluate what number of energy you might be burning every day, it’s finest to have a look at your weight and your skill to shed extra pounds as a proxy measurement of basal metabolic charge.
Most of us have a fairly good thought whether or not or not our our bodies are responding to weight reduction therapies the way in which that they need to.
If you’re having a tough time reducing weight regardless of common train and wholesome consuming or if you’re noticing that you just proceed to achieve weight regardless of consuming fewer energy than regular, then it’s seemingly you’ve got a difficulty together with your metabolism.
On this setting, a trial of T2 supplementation can be very cheap.
#3. Ldl cholesterol
Along with testing your resting coronary heart charge and metabolism, you can even have a look at your ldl cholesterol stage as a proxy measurement of your T2 standing.
Your thyroid is a identified regulator of your ldl cholesterol and when thyroid operate is low, you will note your ldl cholesterol rise.
The low thyroid state is related to a excessive LDL, excessive triglycerides, excessive complete ldl cholesterol, and a low HDL.
This ldl cholesterol sample is typical in those that undergo from insulin resistance and weight problems which implies it’s not an incredible marker by itself.
Nevertheless, there’s a number of curiosity in utilizing T2 and T2 analogs for his or her helpful results on ldl cholesterol metabolism and as a possible therapy for fatty liver (7).
As somebody with thyroid issues, in the event you discover that your ldl cholesterol is mostly excessive and unresponsive to thyroid drugs then you could wish to strive further T2 to assist normalize these ranges.
This marker isn’t good, although, as a result of there are many different components that may impression your ldl cholesterol panel.
#4. T3 and T4 Ranges
You too can try to assess your want for T2 primarily based in your different thyroid hormone ranges.
The rationale this technique may go has to do with how your physique metabolizes and breaks down thyroid hormones.
It’s understood that thyroid hormones, beginning with T4, get metabolized by deiodinase enzymes by taking off iodine molecules.
For those who take away 1 iodine molecule from T4 you’re left with T3.
For those who take away 1 iodine molecule from T3 you’re left with T2.
And in the event you take away 1 iodine molecule from T2 you’re left with T1.
So a technique that you could try to assess your T2 standing is by T4 and T3 ranges.
If we all know that your physique creates T2 from T3 then if you’re low in T3 you most likely received’t have the ability to make very a lot T2.
The identical logic applies when T3 standing.
If the majority of T3 in your physique is created by T4 to T3 conversion then your T4 standing is necessary in your T3 stage.
Whereas this is sensible logically, it’s most likely not as simple as I’ve made it sound.
Some research point out that T2 standing stays unchanged no matter T3 ranges (8).
That is additional difficult by the truth that there are a number of T2 metabolites and that T4 may also be transformed into reverse T3.
How reverse T3 impacts T2 ranges will not be identified, not less than right now.
Even with all of this uncertainty, it’s been my expertise that having low T4 or low T3 is a reasonably good predictor that somebody will do properly when taking T2.
That is most likely as a result of T2 acts as a ligand on the thyroid hormone receptor making it extra delicate to circulating T3 ranges.
Once more, we’re nonetheless figuring all of this out however that is the very best data I may give proper now.
#5. Thyroid Signs
Lastly, you can even use your thyroid signs to assist decide in the event you would profit from further T2.
That is most likely the obvious out of all metrics and the one that everybody ought to perceive the very best.
When you’ve got a thyroid situation and you might be experiencing persistent thyroid signs then there’s probability you most likely want extra thyroid hormone.
That is most likely as a result of most thyroid sufferers are being handled with one thyroid hormone within the type of levothyroxine.
The regulation of thyroid hormone in your physique and in your cells may be very complicated and but most medical doctors deal with this drawback with one thyroid hormone.
It’s very seemingly that every thyroid hormone performs some position within the regulation of thyroid hormones together with T4, T3, T2, and T1.
So, if given the prospect, and if you wish to attempt to replicate the operate of a wholesome thyroid gland, it is sensible to exchange as many of those hormones as doable.
That is most likely why so many sufferers desire thyroid drugs like Armour Thyroid.
Simply because we don’t utterly perceive the operate of all of those hormones doesn’t imply they aren’t necessary.
For that reason, it is sensible for many thyroid sufferers, particularly those that are having bother managing their signs, to strive T2 supplementation.
Recap and Ultimate Ideas
For those who ask me, I feel it’s very seemingly that we’ll see a commercially accessible check for T2 thyroid hormone within the coming years.
And inside the subsequent 10 years, I feel that T2 testing will turn into a part of the usual thyroid panel, that T2 thyroid hormone will make its approach into a number of thyroid drugs (suppose mixture T4 + T2 drugs), and that finally medical doctors will acknowledge the significance of all thyroid hormones.
For those who don’t wish to wait 5-10 years for this to occur, you may all the time get began taking T2 thyroid hormone immediately.
And in the event you do determine to go that route, be sure to are not less than keeping track of the proxy measurements that I’ve talked about above.
Similar to T4 or T3, you don’t wish to take extra of any thyroid hormone than what your physique wants.
Now I wish to hear from you:
Have been you conscious of T2 thyroid hormone earlier than studying this? Or is that this your first time listening to about T2?
Have you considered utilizing T2 earlier than? Did the truth that you may’t check for it cease you?
What do you suppose your private T2 standing is? Do you suppose it is best to strive a T2 complement?
Depart your questions or feedback under!